HRAS1 Proto-Oncogene Polymorphism and Prostate Cancer

Deborah A. Farmer, E. Platz, P. Febbo, M. Stampfer, P. Kantoff, E. Giovannucci
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Abstract

Objectives: Rare HRAS1 variable number tandem repeats (VNTR) have been associated with increased risks for a variety of cancers. We investigated the relationship of this polymorphism with the risk of prostate cancer among 240 cases and 481 control subjects in the Health Professionals Follow-up Study. Materials and Methods: The HRAS1 VNTR region of leukocyte DNA was polymerase chain reaction amplified, and fragment lengths were determined by automated fluorescence detection and computer analysis. We estimated the odds ratios (OR) of prostate cancer for rare HRAS1 VNTR from logistic regression models. Four common HRAS1 VNTR alleles were identified about which there was a distribution of rare 28-nucleotide repeat units. There was no difference (p = 0.4) in the prevalence of rare alleles between cases (25.8%) and control subjects (23.7%). Compared to common alleles, the OR for prostate cancer was 1.13 (95% confidence interval 0.87–1.45) for rare alleles. Conclusions: This study suggests that rare HRAS1 VNTRs may not be important in the etiology of prostate cancer.
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HRAS1原癌基因多态性与前列腺癌
目的:罕见的HRAS1可变数串联重复序列(VNTR)与多种癌症的风险增加有关。我们在卫生专业人员随访研究中调查了240例病例和481名对照受试者的这种多态性与前列腺癌风险的关系。材料与方法:采用聚合酶链反应扩增白细胞DNA HRAS1 VNTR区,通过自动荧光检测和计算机分析确定片段长度。我们通过logistic回归模型估计罕见HRAS1 VNTR患者患前列腺癌的比值比(OR)。鉴定出4个常见的HRAS1 VNTR等位基因,其中有罕见的28个核苷酸重复单位分布。病例(25.8%)与对照组(23.7%)的罕见等位基因患病率差异无统计学意义(p = 0.4)。与普通等位基因相比,罕见等位基因患前列腺癌的OR为1.13(95%可信区间0.87-1.45)。结论:本研究提示罕见的HRAS1 VNTRs可能在前列腺癌的病因中并不重要。
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