O. Rahić, A. Tucak, M. Sirbubalo, Lamija Hindija, J. Hadžiabdić, E. Vranić
{"title":"Opportunities to Topically Reduce Intraocular Pressure in Glaucoma","authors":"O. Rahić, A. Tucak, M. Sirbubalo, Lamija Hindija, J. Hadžiabdić, E. Vranić","doi":"10.9734/OR/2021/V14I230189","DOIUrl":null,"url":null,"abstract":"Since glaucoma is a serious health problem, numerous therapeutics are being developed to reduce Intraocular Pressure (IOP) as the only modifiable factor of all glaucoma symptoms. IOP-lowering agents are divided into six groups, each of which has a specific mechanism of action and side effects, which are the focus of this article and are explained in detail. All the mentioned agents are formulated as eye drops. However, as conventional topical eye drops have significant disadvantages, of which poor bioavailability and patient noncompliance are the main, novel approaches to designing their drug delivery systems were used and briefly presented in this review. Review Article Rahić et al.; OR, 14(2): 17-33, 2021; Article no.OR.66197 18 Graphical Abstract","PeriodicalId":51846,"journal":{"name":"4or-A Quarterly Journal of Operations Research","volume":"59 1","pages":"17-33"},"PeriodicalIF":1.7000,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"4or-A Quarterly Journal of Operations Research","FirstCategoryId":"91","ListUrlMain":"https://doi.org/10.9734/OR/2021/V14I230189","RegionNum":4,"RegionCategory":"管理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPERATIONS RESEARCH & MANAGEMENT SCIENCE","Score":null,"Total":0}
引用次数: 1
Abstract
Since glaucoma is a serious health problem, numerous therapeutics are being developed to reduce Intraocular Pressure (IOP) as the only modifiable factor of all glaucoma symptoms. IOP-lowering agents are divided into six groups, each of which has a specific mechanism of action and side effects, which are the focus of this article and are explained in detail. All the mentioned agents are formulated as eye drops. However, as conventional topical eye drops have significant disadvantages, of which poor bioavailability and patient noncompliance are the main, novel approaches to designing their drug delivery systems were used and briefly presented in this review. Review Article Rahić et al.; OR, 14(2): 17-33, 2021; Article no.OR.66197 18 Graphical Abstract
期刊介绍:
4OR - A Quarterly Journal of Operations Research is jointly published by the Belgian, French and Italian Operations Research Societies. It publishes high quality scientific papers on the theory and applications of Operations Research. It is distributed to all individual members of the participating societies.