{"title":"Presynaptic Calcium Influx","authors":"","doi":"10.1126/scisignal.1252002tw122","DOIUrl":null,"url":null,"abstract":"Neurotransmitter release is triggered by calcium influx through presynaptic voltage-dependent calcium channels. Modulation of presynaptic calcium currents causes a robust alteration in synaptic efficacy. Tsujimoto et al. investigated activity-dependent facilitation of P/Q-type calcium currents at the giant nerve terminals of the calyx of Held and found that calcium current up-regulation is mediated by the calcium-binding protein NCS-1, a homolog of the Drosophila frequenin protein. T. Tsujimoto, A. Jeromin, N. Saitoh, J. C. Roder, T. Takahashi, Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium current at presynaptic nerve terminals. Science 295: 2276-2279 (2002). [Abstract] [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"13 1","pages":"tw122 - tw122"},"PeriodicalIF":0.0000,"publicationDate":"2002-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.1252002tw122","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Neurotransmitter release is triggered by calcium influx through presynaptic voltage-dependent calcium channels. Modulation of presynaptic calcium currents causes a robust alteration in synaptic efficacy. Tsujimoto et al. investigated activity-dependent facilitation of P/Q-type calcium currents at the giant nerve terminals of the calyx of Held and found that calcium current up-regulation is mediated by the calcium-binding protein NCS-1, a homolog of the Drosophila frequenin protein. T. Tsujimoto, A. Jeromin, N. Saitoh, J. C. Roder, T. Takahashi, Neuronal calcium sensor 1 and activity-dependent facilitation of P/Q-type calcium current at presynaptic nerve terminals. Science 295: 2276-2279 (2002). [Abstract] [Full Text]
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