Regulation of Liquid-Liquid Phase Separation by Molecular Chaperones

Soichiro Kawagoe, Eiichiro Mori, T. Saio
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Abstract

Molecular chaperones have been extensively studied as mediators in protein folding and quality control but are recently attracting increasing attention as regulators of liquid-liquid phase separation (LLPS). In this review, we summarize recent studies regarding molecular chaperones involved in LLPS regulation. We also provide a brief introduction of biophysical and structural studies on molecular chaperones in protein folding that depict how the molecular chaperones recognize client proteins and alter the folding process. Although little is known about the mechanism of regulation of LLPS, the understanding of molecular chaperones in protein folding will provide hints for LLPS regulation.
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分子伴侣对液-液分离的调控作用
分子伴侣作为蛋白质折叠和质量控制的介质已被广泛研究,但近年来作为液-液相分离(LLPS)的调节剂引起了越来越多的关注。在这篇综述中,我们总结了最近关于分子伴侣参与LLPS调控的研究。我们还简要介绍了分子伴侣在蛋白质折叠中的生物物理和结构研究,描述了分子伴侣如何识别客户蛋白并改变折叠过程。虽然目前对LLPS的调控机制知之甚少,但了解蛋白质折叠中的分子伴侣将为LLPS的调控提供线索。
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