Co-Occurrence of Filifactor alocis with Red Complex Bacteria in Type 2 Diabetes Mellitus Subjects with and without Chronic Periodontitis: A Pilot Study

H. Shaikh, Pratima U. Oswal, Manohar S. Kugaji, S. Katti, K. Bhat, Vinayak M. Joshi
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Abstract

The periodontal disease etiology has been a demesne of scrupulous research, with a myriad of bacterial phylotypes inhabiting the periodontal pockets. The aim of our study was to assess the frequency of Filifactor alocis in type 2 diabetes mellitus (DM) subjects having a healthy periodontium (DH) or chronic periodontitis (DCP) and its correlation with clinical parameters and red complex bacteria. Polymerase chain reaction was carried out for the detection of F. alocis and red complex bacteria from subgingival plaque samples. The data were analyzed using Fisher’s Exact Test and Pearson’s chi-square test. A p value < 0.05 was considered statistically significant. F. alocis was detected at considerably higher levels in DCP (p < 0.05). F. alocis presence was also positively correlated with T. forsythia detection and the clinical parameters PD and CAL (p < 0.05). Subjects with good glycemic control showed a considerably lower detection of F. alocis as compared to fair- and poor-glycemic-control subjects. This is the first paper reporting the co-occurrence of F. alocis and T. forsythia in diabetic subjects with chronic periodontitis. These findings show that F. alocis can play an important role in establishing synergistic collaborations with other pathogenic oral microorganisms and speeding up the course of periodontal disease in diabetics.
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伴有或不伴有慢性牙周炎的2型糖尿病患者中丝状因子与红色复合体细菌的共同发生:一项初步研究
牙周病的病因学一直是一个严谨的研究,与无数的细菌种型居住在牙周袋。本研究的目的是评估具有健康牙周组织(DH)或慢性牙周炎(DCP)的2型糖尿病(DM)受试者中丝状因子alocis的频率及其与临床参数和红色复合体细菌的相关性。采用聚合酶链反应法对龈下菌斑标本中金黄色梭菌和红色复合体菌进行检测。采用Fisher精确检验和Pearson卡方检验对数据进行分析。p值< 0.05认为有统计学意义。F. alocis在DCP中含量显著高于对照组(p < 0.05)。F. alocis的存在与连翘检出率及临床参数PD、CAL呈正相关(p < 0.05)。血糖控制良好的受试者与血糖控制正常和血糖控制不佳的受试者相比,alocis的检出率明显较低。本文首次报道糖尿病患者慢性牙周炎伴发alocis和连翘t。这些结果表明,alocis在与其他口腔病原微生物建立协同作用,加速糖尿病患者牙周病的进程中发挥重要作用。
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来源期刊
Journal of International Translational Medicine
Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
0.00%
发文量
317
审稿时长
8 weeks
期刊介绍: Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.
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