Neural Implants, Packaging for Biocompatible Implants, and Improving Fabricated Capacitors

Elizabeth R. Agger
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Abstract

We have completed the circuit design and packaging procedure for an NIH-funded neural implant, called a MOTE (Microscale Optoelectronically Transduced Electrode). Neural recording implants for mice have greatly advanced neuroscience, but they are often damaging and limited in their recording location. This project will result in free-floating implants that cause less damage, provide rapid electronic recording, and increase range of recording across the cortex. A low-power silicon IC containing amplification and digitization sub-circuits is powered by a dual-function gallium arsenide photovoltaic and LED. Through thin film deposition, photolithography, and chemical and physical etching, the Molnar Group and the McEuen Group (Applied and Engineering Physics department) will package the IC and LED into a biocompatible implant approximately 100μm. The IC and LED are complete and we have begun refining this packaging procedure in the Cornell NanoScale Science & Technology Facility. ICs with 3D time-resolved imaging capabilities can image microorganisms and other biological samples given proper packaging. A portable, flat, easily manufactured package would enable scientists to place biological samples on slides directly above the Molnar group’s imaging chip. We have developed a packaging procedure using laser cutting, photolithography, epoxies, and metal deposition. Using a flip-chip method, we verified the process by aligning and adhering a sample chip to a holder wafer. In the CNF, we have worked on a long-term metal-insulator-metal (MIM) capacitor characterization project. Former Fellow and continuing CNF user Kwame Amponsah developed the original procedure for the capacitor fabrication, and another former fellow, Jonilyn Longenecker, revised the procedure and began the arduous process of characterization. MIM caps are useful to clean room users as testing devices to verify electronic characteristics of their active circuitry. This project’s objective is to determine differences in current-voltage (IV) and capacitor-voltage (CV) relationships across variations in capacitor size and dielectric type. This effort requires an approximately 20-step process repeated for two-to-six varieties (dependent on temperature and thermal versus plasma options) of the following dielectrics: HfO2, SiO2, Al2O3, TaOx, and TiO2.
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神经植入物,生物相容性植入物的包装,以及改进制造电容器
我们已经完成了美国国立卫生研究院资助的神经植入物的电路设计和封装程序,称为MOTE(微尺度光电转导电极)。小鼠的神经记录植入物具有非常先进的神经科学,但它们通常具有破坏性,并且记录位置有限。这个项目将产生自由漂浮的植入物,造成更少的伤害,提供快速的电子记录,并增加整个皮层的记录范围。包含放大和数字化子电路的低功耗硅集成电路由双功能砷化镓光伏和LED供电。Molnar集团和McEuen集团(应用与工程物理系)将通过薄膜沉积、光刻、化学和物理蚀刻,将IC和LED封装成约100μm的生物相容性植入物。集成电路和LED已经完成,我们已经开始在康奈尔纳米科学与技术设施中改进这种封装程序。具有3D时间分辨成像能力的集成电路可以对微生物和其他适当包装的生物样品进行成像。一种便携、扁平、易于制造的包装将使科学家们能够将生物样本直接放置在莫尔纳团队成像芯片上方的载玻片上。我们已经开发了一种使用激光切割、光刻、环氧树脂和金属沉积的包装程序。使用倒装芯片方法,我们通过对准并粘附样品芯片到支架晶圆来验证该过程。在CNF,我们一直致力于一个长期的金属-绝缘体-金属(MIM)电容器表征项目。前研究员和继续使用CNF的Kwame Amponsah开发了电容器制造的原始程序,另一位前研究员Jonilyn Longenecker修改了程序并开始了艰巨的表征过程。MIM帽对于洁净室用户是有用的测试设备,以验证其有源电路的电子特性。该项目的目标是确定电流-电压(IV)和电容-电压(CV)关系在电容器尺寸和电介质类型变化中的差异。这项工作需要对以下介质(HfO2、SiO2、Al2O3、TaOx和TiO2)的2到6种(取决于温度和热与等离子体的选择)重复大约20步的过程。
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