{"title":"Signaling Through Actin to Regulate Spine Formation and Function","authors":"H. Okada, S. Soderling","doi":"10.2174/1874082000903010097","DOIUrl":null,"url":null,"abstract":"Recent progress has greatly expanded our view of how signaling pathways regulate the actin cytoskeleton in post-synaptic spines. These studies reveal a complex interplay between pathways that highlight the role of the actin cy- toskeleton during the development of spines as well as in response to stimuli that modify synaptic strength. This review discusses the results from these studies that include biochemical, cellular, and genetic approaches to understanding excita- tory synapse formation and function.","PeriodicalId":88753,"journal":{"name":"The open neuroscience journal","volume":"41 1","pages":"97-107"},"PeriodicalIF":0.0000,"publicationDate":"2009-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open neuroscience journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874082000903010097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Recent progress has greatly expanded our view of how signaling pathways regulate the actin cytoskeleton in post-synaptic spines. These studies reveal a complex interplay between pathways that highlight the role of the actin cy- toskeleton during the development of spines as well as in response to stimuli that modify synaptic strength. This review discusses the results from these studies that include biochemical, cellular, and genetic approaches to understanding excita- tory synapse formation and function.
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