Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin
Na Mukungu, K. Abuga, N. Mungai, K. Bosire, E. Karumi
{"title":"Isolation and structural elucidation of compounds from the non-alkaloidal extract of Nicandra physaloides and the antimicrobial activity of withanicandrin","authors":"Na Mukungu, K. Abuga, N. Mungai, K. Bosire, E. Karumi","doi":"10.4314/ECAJPS.V16I2","DOIUrl":null,"url":null,"abstract":"The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, â-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity. Key words: Nicandra physaloides , withanicandrin, β-sitosterol, stigmasterol, antifungal activity.","PeriodicalId":22387,"journal":{"name":"The East and Central African Journal of Pharmaceutical Sciences","volume":"1 1","pages":"49-53"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The East and Central African Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ECAJPS.V16I2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
The aerial parts of Nicandra physaloides plant collected from Kenyatta National Hospital grounds were dried and subjected to acid-base extraction and partitioned to obtain alkaloidal and non-alkaloidal extracts. The non-alkaloidal extract yielded three compounds; withanicandrin, â-sitosterol and stigmasterol after column chromatography. Withanicandrin exhibited antifungal activity against Saccharomyces cerevisiae and Candida albicans but lacked antibacterial activity. Key words: Nicandra physaloides , withanicandrin, β-sitosterol, stigmasterol, antifungal activity.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
