{"title":"Solubility and Solution Thermodynamics of Tylosin in Pure Solvents and Mixed Solvents at Various Temperatures","authors":"Yanmin Shen, Wenju Liu, Zehua Bao, Zhanhu Guo","doi":"10.30919/esmm5f233","DOIUrl":null,"url":null,"abstract":"Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c","PeriodicalId":11851,"journal":{"name":"ES Materials & Manufacturing","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ES Materials & Manufacturing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30919/esmm5f233","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c
药物的热力学数据对工业设计和工业应用具有重要意义。本文在279.75 K ~ 323.15 K范围内实验测定了泰络素在纯溶剂和丙酮+水混合溶剂中的溶解度数据。实验结果表明，泰络素在纯溶剂中的溶解度逐渐降低，其溶解度依次为:氯仿>乳酸丁酯>乙腈>四氢呋喃>丙酮>苯>正丁醇>乳酸乙酯>正丙醇>乙醇>甲醇>水，在水+丙酮混合溶剂中溶解度随水的增加而逐渐降低。除水(x≥c)外，实验溶解度随温度升高而升高
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