Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in the Brain Tissue of Spleen-Yin Deficiency Alzheimer's Disease Rats

World Science and Technology Pub Date : 2011-12-01 DOI:10.1016/S1876-3553(12)60028-3

Zhan Libin , Lin Haiyan , Gong Xiaoyang , Liu Li , Liang Lina

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引用次数: 1

Abstract

The effects of Chinese herbs for Zibu Piyin Recipe (ZBPYR) on spleen-Yin deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-Yin deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-Yin Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (P < 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (P < 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.

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滋补补饮方对脾阴型阿尔茨海默病大鼠脑组织内质网应激的影响

观察中药补脾饮方对脾虚型阿尔茨海默病(AD)大鼠的治疗作用。建立了以AD和脾阴虚证为基础的大鼠模型。然后，测定海马(CA1、CA3和DAG区)和大脑皮层中与内质网应激相关的葡萄糖调节蛋白78 (GRP78)、CCAAT/EBP同源蛋白(CHOP)的表达。结果显示，与脾阴虚AD组相比，GRP78蛋白表达明显上调(P <ZBPYR组为0.05);CHOP蛋白的表达明显下调(P <0.05)。由此可见，中药治疗ZBPYR可能通过增强ERS的存活通路、抑制ERS的凋亡通路来提高学习记忆能力。

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World Science and Technology

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