Study of Calcium Distribution in Alzheimer’s Disease Using Finite Element Technique

Abstract

Alzheimer’s disease is the most common neurodegenerative disorder that is prevailing worldwide. Out of many reasons that may have their roles in prevailing this dementia, higher level of calcium concentration is one of them. There are various parameters that have their hands in maintaining the calcium level of the cytosol. Here we have taken into consideration the buffers and voltage gated calcium channel (VGCC) and used a two dimensional mathematical model to get the desired results. Finite element method (FEM) is employed to carry out the computations. Exogenous buffers like EGTA and BAPTA, which lower down the calcium concentration, have been used in addition to VGCC, which increases the calcium flux at the cytosolic level, to study the impact of calcium in Alzheimer’s disease. The obtained results show that there is increase in calcium concentration level of Alzheimer’s affected cell which render toxicity to the cell followed by cell death in AD.