{"title":"Biosynthesis, metabolism and function of protectins and resolvins","authors":"J. Demarquoy, F. L. Borgne","doi":"10.2217/clp.14.44","DOIUrl":null,"url":null,"abstract":"Abstract N-3 polyunsaturated long chain fatty acids and especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are known to limit inflammation and to improve its resolution. The benefits resulting from the use of EPA and DHA are numerous, they are used for treating asthma and arthritis, for controlling blood pressure and vascular reactivity and have been shown to have antitumor effect. While the effects of these polyunsaturated fatty acids on improving the resolution of inflammation are well evidenced, the mechanisms involved in this process remained unclear until the discovery of protectins and resolvins. The goal of this paper is to give an overview on the biosynthesis, the metabolism and the biochemical and physiological functions of these molecules derived from EPA and DHA.","PeriodicalId":55252,"journal":{"name":"Clinical Lipidology","volume":"70 1","pages":"683 - 693"},"PeriodicalIF":0.0000,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Lipidology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/clp.14.44","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 16
Abstract
Abstract N-3 polyunsaturated long chain fatty acids and especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are known to limit inflammation and to improve its resolution. The benefits resulting from the use of EPA and DHA are numerous, they are used for treating asthma and arthritis, for controlling blood pressure and vascular reactivity and have been shown to have antitumor effect. While the effects of these polyunsaturated fatty acids on improving the resolution of inflammation are well evidenced, the mechanisms involved in this process remained unclear until the discovery of protectins and resolvins. The goal of this paper is to give an overview on the biosynthesis, the metabolism and the biochemical and physiological functions of these molecules derived from EPA and DHA.
期刊介绍：
The Journal of Clinical Lipidology is published to support the diverse array of medical professionals who work to reduce the incidence of morbidity and mortality from dyslipidemia and associated disorders of lipid metabolism. The Journal''s readership encompasses a broad cross-section of the medical community, including cardiologists, endocrinologists, and primary care physicians, as well as those involved in the treatment of such disorders as diabetes, hypertension, and obesity. The Journal also addresses allied health professionals who treat the patient base described above, such as pharmacists, nurse practitioners and dietitians. Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.
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