{"title":"Relationship between H-bonding of penetrants to stratum corneum lipids and diffusion","authors":"W. Pugh","doi":"10.1081/CUS-120001862","DOIUrl":null,"url":null,"abstract":"It is generally accepted that the barrier to permeation is effectively the outermost 10–15mm of the skin (1–3). To overcome this stratum corneum (SC) obstacle, a molecule must first enter and then cross it. Fick’s law relates the steady-state flux, Js, to the concentration gradient across the SC. If the viable dermis is regarded as a sink, the gradient determining the flux is Csc/h. Since the partition coefficient K of a solute between the SC and vehicle can be written as Csc /Cv, Js can be expressed as: Js 1⁄4 ADKCv=h","PeriodicalId":17547,"journal":{"name":"Journal of Toxicology-cutaneous and Ocular Toxicology","volume":"7 1","pages":"303 - 317"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology-cutaneous and Ocular Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1081/CUS-120001862","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
It is generally accepted that the barrier to permeation is effectively the outermost 10–15mm of the skin (1–3). To overcome this stratum corneum (SC) obstacle, a molecule must first enter and then cross it. Fick’s law relates the steady-state flux, Js, to the concentration gradient across the SC. If the viable dermis is regarded as a sink, the gradient determining the flux is Csc/h. Since the partition coefficient K of a solute between the SC and vehicle can be written as Csc /Cv, Js can be expressed as: Js 1⁄4 ADKCv=h
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