Application of Nanoparticles in Diagnostic Imaging via Ultrasonography

V. Mody, R. Siwale
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引用次数: 3

Abstract

The effectiveness of an imaging technique not only depends on its ability to image quantitatively both morphological and physiological functions of the tissue, but also on the contrast agent used to communicate with biomolecules. Several types of contrast media are used in medical imaging and they can roughly be cataloged based on the imaging modalities where they are used. More importantly, the use of contrast agent with their size ranging in nanometer scale has become general practice in medical diagnosis. As the matter of fact, nanoparticles have fascinated scientist for over a century and are now heavily utilized in biomedical sciences and engineering as they are long known to communicate effectively with the biomolecules. Today these materials can be synthesized and modified with various chemical functional groups which allow them to be conjugated with antibodies, ligands, and drugs of interest and thus opening a wide range of potential applications in biotechnology, and more importantly in diagnostic medical imaging via ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). These imaging modalities differ not only in resolution, but also in the instrumentation and the type of nanoparticle that can be employed as its assistant. Of these imaging techniques, ultrasound is one of the oldest imaging modality which is still widely used to examine internal organs of the body and diagnose potential disease states such as cancer, plague, clots, and swelling. Various articles have been published over the period of years detailing the instrumentation and the applications of ultrasonography, but very few have emphasized the importance of particle size in developing a successful contrast agent for ultrasonography. Thus in the present review article we aim to present the basic principles involved in developing successful contrast agent for Ultrasound imaging. Furthermore, we have also discussed the experimental and physical aspects of various types of nanoparticles including its fabrication and design of targeted contrast agents. Finally, we have cited some of the best biomedical and clinical applications of the developed nanoprobes and their use for Ultrasound imaging.
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纳米颗粒在超声诊断成像中的应用
成像技术的有效性不仅取决于其定量成像组织形态和生理功能的能力,还取决于用于与生物分子交流的造影剂。在医学成像中使用了几种造影剂,它们可以根据使用的成像方式大致进行分类。更重要的是,纳米级造影剂的使用已成为医学诊断的普遍做法。事实上,纳米粒子已经吸引了科学家一个多世纪,现在在生物医学科学和工程中大量使用,因为它们长期以来被认为能有效地与生物分子交流。今天,这些材料可以用各种化学官能团合成和修饰,使它们能够与抗体、配体和感兴趣的药物结合,从而在生物技术中开辟了广泛的潜在应用,更重要的是在通过超声、计算机断层扫描(CT)、磁共振成像(MRI)和正电子发射断层扫描(PET)进行医学诊断成像方面。这些成像方式不仅在分辨率上不同,而且在仪器和可用于辅助的纳米颗粒类型上也不同。在这些成像技术中,超声是最古老的成像方式之一,它仍然被广泛用于检查身体的内部器官和诊断潜在的疾病状态,如癌症、瘟疫、血栓和肿胀。在过去的几年里,已经发表了各种各样的文章,详细介绍了超声检查的仪器和应用,但很少有人强调颗粒大小在开发一种成功的超声造影剂中的重要性。因此,在本综述文章中,我们的目的是提出基本原则,涉及开发成功的造影剂的超声成像。此外,我们还讨论了各种类型的纳米颗粒的实验和物理方面,包括其制造和设计靶向造影剂。最后,我们列举了所开发的纳米探针在生物医学和临床方面的一些最佳应用,以及它们在超声成像方面的应用。
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