Catalyst Free One-Pot Synthesis of Chromeno Quinolines and Their Antibacterial Activity

Sruthi Vasamsetty, Sunitha Medidi, Satheesh Ampolu, Ravi Kumar Majji, Mastan Rao Kotupalli, Chikurumilli China Satyanarayana, Annapurna Nowduri, P. Sanasi
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引用次数: 4

Abstract

An efficient greener one pot synthesis of dimethyl-dihydro-7H-chromeno[3, 2-h]quinolin-8(9H)-one derivatives has been synthesized through cyclization of aromatic aldehyde, dimidone and 8-hydroxy-quinoline through one-pot condensation method is described. The synthesized compounds are screened for further biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Bacillus using cut plate method and disc diffusion method.
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无催化剂一锅法合成铬喹啉类化合物及其抑菌活性
以芳香醛、二米酮和8-羟基喹啉为环化原料,采用一锅缩合法合成了高效、绿色的二甲基-二氢- 7h -chromeno[3,2 -h]喹啉-8(9H)- 1衍生物。采用切板法和圆盘扩散法对合成的化合物进行了进一步的抑菌活性筛选,筛选出对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌、枯草芽孢杆菌、芽孢杆菌等的抑菌活性。
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