Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway

2区医学 Q1 Medicine Advances in Cancer Research Pub Date : 2023-01-01 DOI:10.53388/2023623012

Fang-Hua Wu, Fei Huang, Yan Chen, Kui Chen, Chao Gong, Shen-Zhou Huang, Jiang-Yue Yu, Ruohuan Zhao, Peishuo Zhu, Li-Qun Wang

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Abstract

Author contributions Fang-Hua Wu and Fei Huang wrote the original draft; Yan Chen, Kui Chen, Chao Gong, Shen-Zhou Huang, Jiang-Yue Yu, Ruo-Qin Zhao, Pei-Wen Zhu was responsible for reviewing, editing, and supervision; Li-Qun Wang was responsible for project administration, supervision and methodology. Competing interests The authors declare no conflicts of interest. Acknowledgments This work was supported by grants from the Natural Science Foundation of Fujian province (No. 2020J011181). Peer review information Cancer Advances thanks Huang Wei Ling, Huan-Tian Cui and other anonymous reviewers for their contribution to the peer review of this paper. Abbreviations SREBP: sterol regulatory element binding protein; HE: hematoxylin and eosin; qPCR: quantitative polymerase chain reaction; Srebf1: transcription factor 1; Acly: ATP citrate lyase; Acc: acetyl-Coenzyme A carboxylase alpha. Citation Wu FH, Huang F, Chen Y, et al. Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway. Cancer Adv. 2023;6:12. doi: 10.53388/2023623012.

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苦参碱通过SREBP信号通路调控脂质代谢抗肿瘤作用机制的研究

原稿由吴方华、黄飞撰写;陈岩、陈奎、龚超、黄申洲、于江月、赵若琴、朱培文负责审编、监督;王立群负责项目管理、监督和方法论。利益冲突作者声明不存在利益冲突。本研究得到福建省自然科学基金(No. 2020J011181)资助。Cancer Advances感谢黄伟凌、崔焕天等匿名审稿人对本文的同行评议做出的贡献。SREBP:固醇调节元件结合蛋白;HE:苏木精和伊红;qPCR:定量聚合酶链反应;Srebf1:转录因子1;Acly: ATP柠檬酸裂解酶;乙酰辅酶A羧化酶。引用本文吴富华，黄峰，陈勇，等。苦参碱通过SREBP信号通路调控脂质代谢抗肿瘤作用机制的研究。癌症杂志，2023;6:12。doi: 10.53388 / 2023623012。

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来源期刊

Advances in Cancer Research 医学-肿瘤学

CiteScore

10.00

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0.00%

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期刊介绍： Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. The first ACR volume came out in the year that Watson and Crick reported on the central dogma of biology, the DNA double helix. In the first 100 volumes are found many contributions by some of those who helped shape the revolution and who made many of the remarkable discoveries in cancer research that have developed from it.