P. Müller, Benjamin L. Bangasser, L. Greiner, Shukrallah Na’amnieh, P. Bäuerlein, D. Vogt, C. Müller
{"title":"Stable Continuous Operation of a Biphasic Enantioselective Enzymatic Reduction","authors":"P. Müller, Benjamin L. Bangasser, L. Greiner, Shukrallah Na’amnieh, P. Bäuerlein, D. Vogt, C. Müller","doi":"10.2174/1876214X01104010113","DOIUrl":null,"url":null,"abstract":"Continuous operation of alcohol dehydrogenase (ADH) catalysed enantioselective reduction in a biphasic sytem showed gains in productivity and stability of the overall reaction system. The total turnover numbers obtained for the cofactor NADP + are high with up to 1.5� 10 4 . Productivity for (R)-2-butanol with Lactobacillus brevis ADH was up to 26 kmol (mol enzyme) 1 . Enantioselectivity was greater than 0.99 for (R)-phenylethanol and up to 0.99 for (R)-butanol.","PeriodicalId":22755,"journal":{"name":"The Open Catalysis Journal","volume":"9 1","pages":"113-116"},"PeriodicalIF":0.0000,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Catalysis Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876214X01104010113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Continuous operation of alcohol dehydrogenase (ADH) catalysed enantioselective reduction in a biphasic sytem showed gains in productivity and stability of the overall reaction system. The total turnover numbers obtained for the cofactor NADP + are high with up to 1.5� 10 4 . Productivity for (R)-2-butanol with Lactobacillus brevis ADH was up to 26 kmol (mol enzyme) 1 . Enantioselectivity was greater than 0.99 for (R)-phenylethanol and up to 0.99 for (R)-butanol.
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