A Technical Feasibility of Aqueous Aerosol Generation Based on the Flashing Jet: Effects of Overheat Degree, Jetting Rate, Jetting Volume, and Liquid Type

Qiang Zheng, Li-Jia Yuan, Jian Wang
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引用次数: 1

Abstract

Abstract A previously established flashing jet inhaler prototype (FJ prototype) can produce an aqueous aerosol but cannot steadily provide inhalable aerosol (2–5 μm). This study aims to optimize the atomization performance of the FJ prototype and generate inhalable aqueous aerosols. The effects of overheat degree, jetting rate, jetting volume, and liquid type on atomization performance were assessed by determining output aerosol's mass median aerodynamic diameter (MMAD) and aerodynamic particle size distribution. Drug distribution of active ingredients in different liquid types was also measured. A Pari nebulizer was used as a reference device. Our data suggested that MMAD is negatively correlated with the overheat degree and jetting rate, but has no significant relationship with the jetting volume. The effect of jetting rate is weaker than that of the overheat degree. When normal saline was used as the atomization liquid, output aerosol's MMAD at the FJ prototype and Pari nebulizer were 1.98 ± 0.18 and 2.50 ± 0.81 μm, respectively. The addition of a surfactant significantly decreases MMAD both in solution and in suspension, but the suspended particles had no effect on the residual level and atomization performance of the FJ prototype. When ventolin was used as the atomization liquid, the MMAD of the FJ prototype and Pari nebulizer was 2.1 ± 0.2 and 1.7 ± 0.2 μm, respectively, while the fine particle dosage (FPD) in percent of the nominal dose (%ND) was 50.4 ± 3.1 and 53.1 ± 7.2%, respectively. When pulmicort respules was used as the atomization liquid, the MMAD of the FJ prototype and Pari nebulizer was 2.5 ± 0.5 and 4.6 ± 0.2 μm respectively, while the FPD (%ND) was 30.1 ± 5.6 and 58.6 ± 5.1%, respectively. The FJ prototype not only delivers inhalable aqueous aerosol but also has a potential advantage in the atomization of suspension or poorly soluble drugs.
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基于闪蒸射流产生水基气溶胶的技术可行性:过热度、喷射速率、喷射体积和液体类型的影响
先前建立的闪光喷射吸入器原型(FJ原型)可以产生含水气溶胶,但不能稳定地提供2-5 μm的可吸入气溶胶。本研究旨在优化FJ原型机的雾化性能,生成可吸入的水性气溶胶。通过确定输出气溶胶的质量中值气动直径(MMAD)和气动粒径分布,评估了过热度、喷射速率、喷射体积和液体类型对雾化性能的影响。测定了不同液型中有效成分的药物分布。使用Pari喷雾器作为参考装置。我们的数据表明,MMAD与过热度和喷射速率呈负相关,而与喷射量无显著相关。喷射速率的影响小于过热度的影响。以生理盐水作为雾化液时,FJ原型机和Pari雾化器输出气溶胶的MMAD分别为1.98±0.18 μm和2.50±0.81 μm。表面活性剂的加入显著降低了溶液和悬浮液中的MMAD,但悬浮颗粒对FJ原型的残留水平和雾化性能没有影响。雾化液为ventolin时,FJ样机和Pari雾化器的MMAD分别为2.1±0.2和1.7±0.2 μm,细颗粒剂量(FPD)占标称剂量(%ND)的百分比分别为50.4±3.1和53.1±7.2%。以普米克溶液为雾化液时,FJ样机和Pari雾化器的MMAD分别为2.5±0.5和4.6±0.2 μm, FPD (%ND)分别为30.1±5.6和58.6±5.1%。FJ原型不仅提供可吸入的水性气溶胶,而且在悬浮液或难溶性药物的雾化方面具有潜在的优势。
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