Toll-Like Receptors as a Potential Marker of Aggressive Periodontitis in Indonesian Population

Abstract

ABSTRACT Toll-like receptorsplay a role as a bridge between innate immune system and adaptive immune system, playing an important role in body'sdefense against invading germs. Thus, theintroduction of TLR-4can be used as a marker for aggressive and chronic periodontitis. This researchaimed to analyze the expression of TLR-4in patients with aggressive and chronic periodontitis. The samplesin this study were derived from tissue suffering from aggressive and chronic periodontitis. The number of samples in this research was 40 patients with aggressive periodontitis and 40 patients with chronic periodontitis. Then, TLR-4 expression test was conducted by using immunohistochemistry.Based on the results of T-test, a statistical test, it is known that t value was 5.697 with significant value about 0.000 (α = 5%). It is also known that there was significant difference of TLR4 protein expression between in patients with aggressive periodontitis and in those with chronic periodontitis. Morever, based on a box plot diagram, it is known that there was significant difference of TLR4 protein distribution between in patients with aggressive periodontitis and in those with chronic periodontitis. Besides, it is also known that TLR4 protein expression has an effect on the incidence of patients with aggressive periodontitis and chronic periodontitis, as well as the shape of the regression equation. Furthermore, it is known that OR estimated value for the variable expression of TLR4 protein was 1.275 (sign = 0.000). It indicates that if TLR4 protein expression increased 1 (one) unit, then the risk of aggressive periodontitis could be 1,275 times. Conclusion: The increasing of TLR4 protein expression in patients with aggressive periodontitis indicates that cytokine becomes an indicator of inflammation in aggressive periodontitis. Keywords: Toll - like receptors -4, aggressive eriodontitis, chronic periodontitis