STUDYING THE CHEMICAL STABILITY OF TRICLABENDAZOLE-BASED PREPARATIONS

THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL Pub Date : 2023-04-17 DOI:10.31016/978-5-6048555-6-0.2023.24.493-497

M. Khalikov

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Abstract

The purpose of the research is to study the chemical stability of triclabendazole (TCB) in preparations obtained by its mechanochemical modification with polymeric substances and succinic acid (SA), as well as samples of Triclafascid obtained in 2015–2022 and left for storage at a temperature of 18–25 0C and a relative humidity of 55–60%. To achieve this goal, we selected samples of preparations obtained earlier and in freshly prepared solid dispersions (SD) based on TCB, SA, polyvinylpyrrolidone (PVP) and arabinogalactan (AG). Modification of TCB by polymeric substances was carried out at a weight ratio of components 1:9 in an LE101 ball mill at a rotation speed of 65–70 rpm with sampling for stability (integrity) analysis of TCB by high performance liquid chromatography (HPLC). The integrity analysis of TCB in its SDs obtained in 2015–2022 showed that there was no chemical destruction of TCB in them. The TCB substance is a stable chemical molecule that is not affected by destruction either during machining or during succinic acid treatment. The obtained SDs remain stable for TCB during storage for more than 7 years.

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研究了三氯苯达唑基制剂的化学稳定性

本研究的目的是研究三氯苄唑(TCB)在聚合物物质和琥珀酸(SA)机械化学改性后的制剂中的化学稳定性，以及2015-2022年获得的Triclafascid样品，保存温度为18-25℃，相对湿度为55-60%。为了实现这一目标，我们选择了早期获得的制剂样品和新制备的基于TCB、SA、聚乙烯吡咯烷酮(PVP)和阿拉伯半乳聚糖(AG)的固体分散体(SD)。采用LE101球磨机，在65 ~ 70 rpm转速下，以组分重量比为1:9对TCB进行高分子改性，并取样，采用高效液相色谱法(HPLC)分析TCB的稳定性(完整性)。2015-2022年获得的SDs中TCB的完整性分析表明，其中TCB没有化学破坏。TCB物质是一种稳定的化学分子，在加工或琥珀酸处理过程中不受破坏。得到的SDs在TCB中保存7年以上保持稳定。

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THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL

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