Efficacy and Safety of Prophylactic-Dose Anticoagulation Therapy with Intermediate-Therapeutic Doses in Covid-19 Patients
D. Kurniawati, A. Subagjo, L. Djuari
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Abstract
Introduction: Coronavirus Disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARSCoV-2) was declared a worldwide pandemic on March 11, 2020 and globally, on April 29, 2022, there were 510,270,667 confirmed COVID-19 cases, including 6,233,526 deaths, reported to WHO. As of April 2022, the Government of the Republic of Indonesia has reported 4,249,323 confirmed cases of COVID-19. There have been 143,592 COVID-19-related deaths reported and 4,096,194 patients have recovered from the disease. COVID-19 is associated with a high risk of venous thromboembolism (VTE), however, to date, optimal prophylactic anticoagulant therapy remains uncertain and may depend on the severity of COVID-19. Objective(s): The aim of this study was to determine the difference in efficacy and safety in administering prophylactic doses with intermediate/therapeutic doses in confirmed COVID-19 patients. Result(s): This study used 6 studies that met the inclusion of differences in efficacy and safety in administering prophylactic doses with intermediate/therapeutic doses in confirmed COVID-19 patients. Conclusion(s): From 6 studies, there were 2 studies comparing anticoagulant prophylactic doses with intermediate doses and 4 studies comparing anticoagualnt prophylactic doses with therapeutic doses. In all studies, there were no significant differences in thromboembolic events or all-cause mortality in COVID-19 patients. The incidence of bleeding at the intermediate and therapeutic doses increased compared to the prophylactic dose, but the difference was not significant. Copyright © 2023, Institute of Medico-legal Publication. All rights reserved.
预防剂量中剂量抗凝治疗在Covid-19患者中的疗效和安全性
2020年3月11日,由严重急性呼吸综合征冠状病毒-2 (SARSCoV-2)引起的冠状病毒病-19 (COVID-19)被宣布为全球大流行。截至2022年4月29日,世卫组织报告的全球COVID-19确诊病例为510,270,667例,其中包括6,233,526例死亡。截至2022年4月,印度尼西亚共和国政府报告了4249323例COVID-19确诊病例。据报告,与covid -19相关的死亡人数为143592人,康复患者为4096194人。COVID-19与静脉血栓栓塞(VTE)的高风险相关,然而,迄今为止,最佳预防性抗凝治疗仍不确定,可能取决于COVID-19的严重程度。目的:本研究的目的是确定在确诊的COVID-19患者中给予预防剂量与中间/治疗剂量的疗效和安全性差异。结果:本研究纳入了6项研究,这些研究符合对确诊COVID-19患者给予预防剂量与中间/治疗剂量的疗效和安全性差异的纳入。结论:6项研究中,2项研究比较了抗凝预防剂量与中间剂量,4项研究比较了抗凝预防剂量与治疗剂量。在所有研究中,COVID-19患者的血栓栓塞事件或全因死亡率没有显著差异。与预防剂量相比,中间剂量和治疗剂量的出血发生率增加,但差异不显著。版权所有©2023,医学法律出版研究所。版权所有。
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