Experimental Evaluation and Modeling of Adsorption Phenomena of Nanoliposomes on Poly(dimethylsiloxane) Surfaces

Pub Date : 2021-06-11 DOI:10.2494/photopolymer.34.1
Sylvan Sunny Koyagura, Virendra Majarikar, H. Takehara, T. Ichiki
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Abstract

Nanoparticles, such as exosomes or liposomes, have been widely studied using poly(dimethylsiloxane) (PDMS) microchannels. The interaction between nanoparticles and solid surfaces is an important subject for basic and applied research on nanoparticles, but there have been few reports on the use of microchannels for this purpose. Micro-scale systems serve as a useful platform for adsorption analysis because of their large surface-tovolume ratio. In this study, we attempted to develop a platform to study the adsorption phenomena of nanoparticles on solid surfaces using a microchannel, in which a model that analyzes dynamic (i.e., non-equilibrium) adsorption was used. This model allowed quantitative analysis of nanoliposome adsorption onto the surface of a PDMS microchannel.
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纳米脂质体在聚二甲基硅氧烷表面吸附现象的实验评价与建模
利用聚二甲基硅氧烷(PDMS)微通道对外泌体或脂质体等纳米颗粒进行了广泛的研究。纳米颗粒与固体表面的相互作用是纳米颗粒基础研究和应用研究的重要课题,但利用微通道进行这方面研究的报道很少。微尺度系统由于其大的表面体积比而成为吸附分析的有用平台。在这项研究中,我们试图开发一个平台来研究纳米颗粒在固体表面上使用微通道的吸附现象,其中使用了一个分析动态(即非平衡)吸附的模型。该模型允许定量分析纳米脂质体吸附到PDMS微通道表面。
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