{"title":"具有对称结构手性氨基酚化合物的合成 Synthesis of Symmetric Chiral Aminophenol Compounds","authors":"杜婷, 张奎, 赵松, 张旭龙, 黄艳","doi":"10.12677/JOCR.2017.52017","DOIUrl":null,"url":null,"abstract":"分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"207 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Organic Chemistry Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12677/JOCR.2017.52017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.
具有对称结构手性氨基酚化合物的合成 Synthesis of Symmetric Chiral Aminophenol Compounds
分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.
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