Cytokine gene single nucleotide polymorphisms associated with infectious endocarditis

Abstract

Infectious endocarditis is a disease with the primary pathogen localization on the heart valves and the mural endocardium, occurring with the possible generalization of the septic process and the immunopathological changes that are very significant in the disease manifestation and course. Based on the fact that 30–50% of cases concerning infectious endocarditis develop without the obvious involvement of standard risk factors (invasive procedures or endovascular disorders), it can be assumed that molecular genetic factors are involved in the disease pathogenesis and its complications. There is reason to believe that the activation of inadequate inflammation in response to the microbial invasion may be due to polymorphism in the genes controlling the cytokine activity. However, the information available today on the various cytokines level and the gene polymorphism in various clinical variants of infectious endocarditis is very limited and commonly contradictory, which requires a deeper study of the pathogenetic association of infectious endocarditis with cytokine genetic defects. In this regard, the expansion of ideas concerning the of cytokine gene polymorphisms in the form of point mutations (SNP), capable of regulating the intensity of cytokine expression and their biological effects, will allow to predict the risk of infectious endocarditis, the severity of its course, the risk of possible complications, as well as the individual treatment tactics for patients. KEYWORDS: infectious endocarditis, clinical variants, complications, cytokines, cytokine genes, genetic polymorphism, pathogenesis, diagnosis. FOR CITATION: Samoylenko E.S., Kolesnikova N.V. Cytokine gene single nucleotide polymorphisms associated with infectious endocarditis. Russian Medical Inquiry. 2023;7(7) (in Russ.). DOI: 10.32364/2587-6821-2023-7-7-2.