Synthesis, Biological Activity and Applications of 1,2,5-Oxadiazol: A Brief Review

J. R. D. F. Filho, J. C. R. Freitas, J. Freitas, C. Ramos, F. A. M. D. Souza, Jaqueline Ferreira Ramos, Ricarte Tavares, Drielly Emanoele Tomé Barros De Oliveira
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引用次数: 2

Abstract

Oxadiazoles are heterocyclic compounds that belong azole class which contain two nitrogen atoms and one oxygen, forming a five-membered heterocyclic ring. Four isomers of oxadiazoles are described in the literature. Among these, 1,2,4-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole have several applications biological. Compounds of this type have been used in the treatment of various diseases in both humans and animals.Among the immense class of heterocycle compounds with important biological activities already identified, the 1,2,5-oxadiazoles have stood out for the wide variety of applications in medicinal chemistry, in material, and agricultural chemistry. In this work, the main synthesis methods and advances for obtaining 1,2,5-oxadiazoles and their derivatives reported in the literature over the years are reviewed, as well as the applications of these compounds in several branches of chemistry and their biological activities discovered until the moment.
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1,2,5-恶二唑的合成、生物活性及应用综述
恶二唑是由两个氮原子和一个氧原子组成的五元杂环,属于唑类的杂环化合物。文献中描述了四种恶二唑的异构体。其中1,2,4-恶二唑、1,2,5-恶二唑和1,3,4-恶二唑具有多种生物学应用。这类化合物已被用于治疗人类和动物的各种疾病。在已发现的具有重要生物活性的杂环化合物中,1,2,5-恶二唑在药物化学、材料化学和农业化学等方面的应用最为广泛。本文综述了近年来文献报道的1,2,5-恶二唑及其衍生物的主要合成方法和进展,以及这些化合物在几个化学分支中的应用和迄今为止发现的生物活性。
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