Pulse inversion Doppler: a new method for detecting nonlinear echoes from microbubble contrast agents

1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118) Pub Date : 1997-10-05 DOI:10.1109/ULTSYM.1997.663301

D. Simpson, P. Burns

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引用次数: 207

Abstract

A novel technique for the selective detection of ultrasound contrast agents, called pulse inversion Doppler, has been developed. In this technique, a conventional Doppler pulse sequence is modified by inverting every second transmit pulse. Either conventional or harmonic Doppler processing is then performed on the received echoes. In the resulting Doppler spectra, Doppler shifts from linear and nonlinear scattering are separated into two distinct regions which can be analyzed separately or combined to estimate the ratio of nonlinear to linear scattering from a region of tissue. The maximum Doppler shift which can be detected is 1/2 the normal Nyquist limit. In vitro measurements comparing flowing agent and cellulose particles suggest that pulse inversion Doppler can provide 3 to 10 dB more agent to tissue contrast than harmonic imaging with similar pulses. Similar measurements suggest that broadband pulse inversion Doppler can provide up to 16 dB more contrast than broadband conventional Doppler.

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脉冲逆多普勒:一种检测微泡造影剂非线性回波的新方法

一种用于超声造影剂选择性检测的新技术，称为脉冲反转多普勒，已经发展起来。在这种技术中，传统的多普勒脉冲序列通过反转每秒钟发射脉冲来修改。然后对接收到的回波进行常规或谐波多普勒处理。在得到的多普勒光谱中，线性和非线性散射的多普勒频移被分成两个不同的区域，可以单独分析或组合分析，以估计组织区域的非线性和线性散射的比率。可以检测到的最大多普勒频移是正常奈奎斯特极限的1/2。对比流动剂和纤维素颗粒的体外测量表明，脉冲反转多普勒成像比相似脉冲的谐波成像能多提供3 ~ 10 dB的组织造影剂。类似的测量表明，宽带脉冲反转多普勒比宽带常规多普勒提供高达16 dB的对比度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118)

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