{"title":"Measurement of organ blood flow with coloured microspheres: a first time-saving improvement using automated spectrophotometry","authors":"W. Wieland, P. Wouters, H. Van Aken, W. Flameng","doi":"10.1109/CIC.1993.378308","DOIUrl":null,"url":null,"abstract":"The authors report on the development and application of automated spectrophotometry for regional blood flow measurement using the coloured microsphere (CM) dye-extraction technique. A software program running under Microsoft Windows 3.1 was written to simultaneously control an autosampler, sipper pump, pressure valves and spectrophotometer with an exclusively designed small-volume flow-cell. The system allowed consecutive measurements of over 200 tissue samples in volumes as small as 40 /spl mu/L without any attendance. The system was validated in eight chronically instrumented dogs. A comparison between the advanced CM technique and the standard radionuclide microspheres method demonstrated a strong correlation for blood flows to various organs in awake animals. The system proved to be a reliable, user-friendly and time-saving application for the CM dye-extraction technique.<<ETX>>","PeriodicalId":20445,"journal":{"name":"Proceedings of Computers in Cardiology Conference","volume":"24 1","pages":"691-694"},"PeriodicalIF":0.0000,"publicationDate":"1993-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"33","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of Computers in Cardiology Conference","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/CIC.1993.378308","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 33
Abstract
The authors report on the development and application of automated spectrophotometry for regional blood flow measurement using the coloured microsphere (CM) dye-extraction technique. A software program running under Microsoft Windows 3.1 was written to simultaneously control an autosampler, sipper pump, pressure valves and spectrophotometer with an exclusively designed small-volume flow-cell. The system allowed consecutive measurements of over 200 tissue samples in volumes as small as 40 /spl mu/L without any attendance. The system was validated in eight chronically instrumented dogs. A comparison between the advanced CM technique and the standard radionuclide microspheres method demonstrated a strong correlation for blood flows to various organs in awake animals. The system proved to be a reliable, user-friendly and time-saving application for the CM dye-extraction technique.<>
本文报道了彩色微球(CM)染料提取技术在区域血流量测量中的应用。在Microsoft Windows 3.1下编写了一个软件程序，用于同时控制一个专门设计的小体积流动池的自动进样器、小泵、压力阀和分光光度计。该系统允许连续测量200多个组织样品，体积小至40 /spl mu/L，无需任何人员。该系统在8只长期使用仪器的狗身上进行了验证。先进的CM技术与标准的放射性核素微球方法的比较表明，清醒动物各器官的血流具有很强的相关性。该系统被证明是一种可靠的、用户友好的、节省时间的CM染料提取技术应用。
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