Kinetic and Mechanistic study of Oxidative Transformation of Some Amino acid by Pyridiniumchlorochromate in DMF-Water Medium

Abstract

Oxidation of L-isoleucine and L-valine by PCC was studied in the presence of perchloric acid in DMFH2O medium at 400C. The kinetics of the reaction was followed spectrophotometrically at λ max = 354 nm. The reaction is unit dependence on each of PCC, [H + ] and [substrate]. Michaelis-Menten type kinetics was observed with different amino acid. The reactions were studied at different temperature [25, 30, 35, 40, 45,500C] and activation parameters were computed. The effect of dielectric constant of the medium on the rate was studied. A mechanism consistent with the observed results has been proposed.