Promieniowanie jonizujące jako czynnik wspomagający różnicowanie komórek macierzystych

Zeszyty Naukowe WCO, Letters in Oncology Science Pub Date : 2015-07-01 DOI:10.1016/j.onko.2015.09.002

Wiktoria M. Suchorska, Adam A. Mieloch

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Abstract

Efficient stem cell differentiation is considered to be the future of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for further improvement in differentiation efficiency remains. This review contains a description of molecular processes underlying the response of stem cells to ionizing radiation, indicating its potential application in differentiation procedures. In the first part, the radiation-induced damage response in various types of stem cells is described. Second, the role of the p53 protein in embryonic and adult stem cells is highlighted. Last, the hypothesis on the mitochondrial involvement in stem cell development including its response to ionizing radiation is presented. In summary, subjecting cells to the appropriate dosage of ionizing radiation may become a useful method for enhancing directed differentiation in certain stem cell types.

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高效的干细胞分化被认为是再生医学的未来。追求最有成效的定向分化方法一直是许多研究的主题，导致许多有效方案的发展。但是，进一步提高差异化效率的必要性仍然存在。这篇综述包含了干细胞对电离辐射反应的分子过程的描述，表明其在分化过程中的潜在应用。在第一部分中，描述了各种类型干细胞的辐射诱导损伤反应。其次，强调了p53蛋白在胚胎和成体干细胞中的作用。最后，提出了线粒体参与干细胞发育及其对电离辐射反应的假说。总之，使细胞接受适当剂量的电离辐射可能成为增强某些干细胞类型定向分化的有用方法。

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Zeszyty Naukowe WCO, Letters in Oncology Science

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