Phytoecdysteroids: A Novel, Non-Androgenic Alternative for Muscle Health and Performance

Kevin A Zwetsloot Andrew R Shanely, E. Merritt, J. McBride
{"title":"Phytoecdysteroids: A Novel, Non-Androgenic Alternative for Muscle Health and Performance","authors":"Kevin A Zwetsloot Andrew R Shanely, E. Merritt, J. McBride","doi":"10.4172/2157-7536.S12-E001","DOIUrl":null,"url":null,"abstract":"Skeletal muscle is the most abundant tissue in the adult human body, comprising more than 40% of total body mass in normal, healthy individuals [1], and is required for movement and locomotion. Muscle mass (volume) is an important determinant of muscle function, such that physiological cross-sectional area is correlated to peak isometric force [2,3]. The maintenance of skeletal muscle mass exists as a delicate balance between the rates of muscle protein synthesis and muscle protein degradation. Rates of muscle protein synthesis and degradation are finely tuned according to activity level, nutrient availability, and health status. For example, rates of muscle protein synthesis are positively influenced by exercise and nutrition, and negatively regulated by inactivity (e.g. disuse), aging (i.e. sarcopenia), and muscle wastingrelated diseases (e.g. cancer) [4]. The PI3K/Akt signaling pathway controls both catabolic and anabolic mechanisms in skeletal muscle. Activating this pathway through exercise and nutritional interventions has a positive effect on skeletal muscle. Phytoecdysteroids (PEs) are natural steroid analogs synthesized by many plant species that possess biological, pharmacological, and medicinal properties with no known side effects in mammals [5], and are believed toelicitanabolic effects on skeletal muscle, in a non-androgenic manner,via activation of the PI3K/Akt signaling pathway.","PeriodicalId":17132,"journal":{"name":"Journal of steroids & hormonal science","volume":"17 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of steroids & hormonal science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2157-7536.S12-E001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10

Abstract

Skeletal muscle is the most abundant tissue in the adult human body, comprising more than 40% of total body mass in normal, healthy individuals [1], and is required for movement and locomotion. Muscle mass (volume) is an important determinant of muscle function, such that physiological cross-sectional area is correlated to peak isometric force [2,3]. The maintenance of skeletal muscle mass exists as a delicate balance between the rates of muscle protein synthesis and muscle protein degradation. Rates of muscle protein synthesis and degradation are finely tuned according to activity level, nutrient availability, and health status. For example, rates of muscle protein synthesis are positively influenced by exercise and nutrition, and negatively regulated by inactivity (e.g. disuse), aging (i.e. sarcopenia), and muscle wastingrelated diseases (e.g. cancer) [4]. The PI3K/Akt signaling pathway controls both catabolic and anabolic mechanisms in skeletal muscle. Activating this pathway through exercise and nutritional interventions has a positive effect on skeletal muscle. Phytoecdysteroids (PEs) are natural steroid analogs synthesized by many plant species that possess biological, pharmacological, and medicinal properties with no known side effects in mammals [5], and are believed toelicitanabolic effects on skeletal muscle, in a non-androgenic manner,via activation of the PI3K/Akt signaling pathway.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
植物甾体:一种新的、非雄激素的肌肉健康和性能替代品
骨骼肌是成年人体内最丰富的组织,在正常、健康的个体中,骨骼肌占总体重的40%以上[1],是运动和运动所必需的。肌肉质量(体积)是肌肉功能的重要决定因素,因此生理横截面积与峰值等距力相关[2,3]。骨骼肌质量的维持是肌肉蛋白质合成率和肌肉蛋白质降解率之间的微妙平衡。肌肉蛋白质的合成和降解率是根据活动水平、营养可利用性和健康状况精细调整的。例如,肌肉蛋白质合成速率受到运动和营养的积极影响,而受到不运动(如废弃)、衰老(如肌肉减少症)和肌肉萎缩相关疾病(如癌症)的负面调节[4]。PI3K/Akt信号通路控制骨骼肌的分解代谢和合成代谢机制。通过锻炼和营养干预激活这一途径对骨骼肌有积极作用。植物甾体激素(Phytoecdysteroids, PEs)是由许多植物合成的天然类固醇类似物,具有生物学、药理学和药用特性,对哺乳动物无已知副作用[5],被认为通过激活PI3K/Akt信号通路,以非雄激素的方式对骨骼肌产生促代谢作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Editorial Note for Journal of Steroids and Hormonal Science Implications of Androgen Receptor Hyperstimulation by the FKBP51 L119P Mutation: No Evidence for Early Emergence of L119P in Prostate Cancer Marine Sourced Bioactive Steroidal Compounds as Potential Cytotoxic Agents against Various Cancer Cell Lines Modern Parathyroid Surgery and Intra-Operative Hormone Monitoring; Present Status, Future Concepts The Role of Steroids and Hormones in Gynecomastia-Factors and Treatments
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1