Coexistence of Multiple Sclerosis and Alzheimer Disease Pathology: A Case Series

Pauline Luczynski, C. Laule, G. Hsiung, G. Moore, H. Tremlett
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引用次数: 1

Abstract

Individuals with multiple sclerosis (MS) are now living close to normal lifespans and will likely suffer from the same diseases of aging as the general population. However, the coexistence of MS with diseases of aging remains poorly understood. In particular, little information exists describing the coexistence of MS with Alzheimer’s disease (AD), the most common form of dementia. In this case series, we searched a post-mortem pathological (autopsy) report database of the Vancouver General Hospital, Vancouver Coastal Health Authority in British Columbia, Canada to identify individuals with neuropathological features of both MS and AD. To complement the data from the autopsy reports, we accessed the medical records of the patients identified. Our search identified four individuals with pathological features of both MS and AD: three females and one male. Two individuals had pre-mortem diagnoses of MS while two did not. None of the patients with AD pathology had pre-mortem diagnoses of AD. In summary, this case series adds to the sparse literature describing the coexistence of these two relatively common neurological conditions and advances our understanding of the clinical and pathological features individuals with both MS and AD may present with. J Neurol Res. 2021;11(3-4):60-67 doi: https://doi.org/10.14740/jnr666
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多发性硬化症与阿尔茨海默病病理共存:一个病例系列
患有多发性硬化症(MS)的人现在的寿命接近正常寿命,他们可能会像一般人一样患上与衰老有关的疾病。然而,MS与衰老疾病的共存仍然知之甚少。特别是,很少有信息描述MS与阿尔茨海默病(AD)共存,AD是最常见的痴呆形式。在本病例系列中,我们检索了加拿大不列颠哥伦比亚省温哥华海岸卫生局温哥华总医院的尸检报告数据库,以确定具有多发性硬化症和阿尔茨海默病神经病理特征的个体。为了补充尸检报告中的数据,我们查阅了已确认的患者的医疗记录。我们的研究确定了四个人同时具有MS和AD的病理特征:三名女性和一名男性。其中两个人死前被诊断患有多发性硬化症,另外两个人则没有。无AD病理患者死前诊断为AD。总之,本病例系列增加了描述这两种相对常见的神经系统疾病共存的稀少文献,并提高了我们对MS和AD患者可能呈现的临床和病理特征的理解。中华神经科杂志。2021;11(3-4):60-67 doi: https://doi.org/10.14740/jnr666
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