Genesis of ER Stress in Huntington’s Disease

IF 0.7 Cell Pathology Pub Date : 2015-01-01 DOI:10.1515/ersc-2015-0007
M. Shenkman, Hagit Eiger, G. Lederkremer
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引用次数: 3

Abstract

Abstract Recent research has identified ER stress as a major mechanism implicated in cytotoxicity in many neurodegenerative diseases, among them Huntington’s disease. This genetic disorder is of late-onset, progressive and fatal, affecting cognition and movement. There is presently no cure nor any effective therapy for the disease. This review focuses on recent findings that shed light on the mechanisms of the advent and development of ER stress in Huntington’s disease and on its implications, highlighting possible therapeutic avenues that are being or could be explored.
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内质网应激在亨廷顿氏病中的成因
最近的研究已经确定内质网应激是许多神经退行性疾病(包括亨廷顿病)中涉及细胞毒性的主要机制。这种遗传性疾病是一种迟发性、进行性和致命性的疾病,影响认知和运动。目前还没有治愈这种疾病的方法,也没有有效的治疗方法。这篇综述的重点是最近的发现,揭示了内质网应激在亨廷顿病中的出现和发展的机制及其影响,强调了可能的治疗途径,正在或可能探索。
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