THE MOUSE EAR AS A MODEL FOR CUTANEOUS IRRITATION

M. Gábor
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引用次数: 11

Abstract

In the past two decades, a number of papers and monographs have dealt with different aspects of inflammation. These include laboratory models for the testing of anti-inflammatory drugs, experimental models of inflammation, etc. Many models of inflammation have been developed, but those that involve the skin offer a particular advantage. In particular for the screening of new drugs for the topical treatment of inflammatory skin diseases, strong emphasis should be placed on mouse ear models. In the following I shall deal with skin irritants, with mouse ear edema, and with the different types of mouse ear inflammation models, including irritation induced with croton oil, 12-O-tetradecanoylphorbol-13-acetate (TPA), cantharidin, mustard oil, arachidonic acid, dithranol (anthralin), capsaicin, ethyl phenylpropiolate (EPP), interleukin-1 (IL-1), zymosan, or carrageenin.
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小鼠耳作为皮肤刺激模型
在过去的二十年里,许多论文和专著都涉及了炎症的不同方面。其中包括抗炎药物试验的实验室模型、炎症实验模型等。许多炎症模型已经被开发出来,但那些涉及皮肤的模型提供了一个特别的优势。特别是对于外用治疗炎症性皮肤病的新药的筛选,应重点关注小鼠耳模型。下面我将讨论皮肤刺激物、小鼠耳部水肿以及不同类型的小鼠耳部炎症模型,包括巴豆油、12- o -十四烷醇-13-乙酸酯(TPA)、斑斑素、芥菜油、花生四烯酸、二糖醇(炭疽素)、辣椒素、苯基丙酸乙酯(EPP)、白细胞介素-1 (IL-1)、酶生蛋白或角叉菜素引起的刺激。
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