H. Matsumoto, Toshitsugu Taguri, T. Teshima, H. Koyama
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引用次数: 0
Abstract
: The emergence of antimicrobial-resistant pathogens has significantly affected treatment outcomes for malasseziosis and pyoderma in dogs. Here, we determined the antimicrobial activity of plant-derived polyphenols against Malassezia pachydermatis and S. intermedius , the causative agents of malasseziosis and SIG infection, respectively. The polyphenols tested were castalagin, (+)catechin, ( − )-epigallocatechin, ( − )-epicatechin gallate, ( − )-epigallocatechin-3-O-gallate, myricitrin, prodelphinidin, procyanidin, resveratrol, rutin, theaflavin, and thearubigin. Minimum inhibitory concentration (MIC) values of these polyphenols against two yeast species, M. pachydermatis and Candida albicans , and two bacterial species, S. intermedius and Achromobacter xylosoxidans , were determined using an agar plate assay. Castalagin had the lowest MIC values against M. pachydermatis (100 μg/ml) and S. intermedius (50 μg/ml), suggesting its therapeutic potential for skin diseases caused by these microbes in dogs.
耐药病原体的出现显著影响了犬马拉色菌病和脓皮病的治疗结果。在这里，我们测定了植物源多酚对厚皮马拉色菌和中间沙门氏菌的抗菌活性，这两种马拉色菌分别是马拉色菌病和SIG感染的病原体。测试的多酚为castalagin，(+)儿茶素，(−)-表没食子儿茶素，(−)-表没食子儿茶素没食子酸酯，(−)-表没食子儿茶素-3- o -没食子酸酯，杨梅三苷，prodelphinidin，原花青素，白藜芦醇，芦丁，茶黄素和红豆素。用琼脂平板法测定了这些多酚对厚皮分枝杆菌和白色念珠菌两种酵母菌以及中间葡萄球菌和木糖氧化无色杆菌两种细菌的最小抑制浓度(MIC)值。Castalagin对厚皮分枝杆菌(100 μg/ml)和中间分枝杆菌(50 μg/ml)的MIC值最低，提示其对厚皮分枝杆菌引起的犬皮肤病具有治疗潜力。
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