Mohaddeseh Parvand, Fahimeh Nemati Mansour, J. Amani
{"title":"Design and Production of Recombinant TAT Protein Structure, Catalytic Domain of Diphtheria Toxin, and Evaluation of Its Effect on Cell Line","authors":"Mohaddeseh Parvand, Fahimeh Nemati Mansour, J. Amani","doi":"10.29252/qums.13.9.19","DOIUrl":null,"url":null,"abstract":"Received: 30 May, 2019 Accepted: 15 Oct, 2019 Abstract Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical specialists. Diphtheria toxin consists of three functional, transducing, and binding domains, that the functional part inhibits protein synthesis and causes cell death. The purpose of this study was to produce the functional domain of the diphtheria toxin fused with a TAT penetrating peptide and to investigate its degree of lethality on cell line.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"142 1","pages":"19-33"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Qom University of Medical Sciences Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29252/qums.13.9.19","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Received: 30 May, 2019 Accepted: 15 Oct, 2019 Abstract Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical specialists. Diphtheria toxin consists of three functional, transducing, and binding domains, that the functional part inhibits protein synthesis and causes cell death. The purpose of this study was to produce the functional domain of the diphtheria toxin fused with a TAT penetrating peptide and to investigate its degree of lethality on cell line.
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