Role of Blood Retinal Barrier in Drug Absorption

Tyagi A, S. Pk, Malviya R
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引用次数: 5

Abstract

The blood-retinal barrier is the one of the earliest retinal changes in diabetes. The blood retinal barrier is a physiological barrier that regulates ion, protein and water flux in inner and outer retina. In blood-retinal barrier function vitreous fluorophotometry technique is an excellent technique to quantitate. The two most relevant retinal diseases are diabetic retinopathy and age related macular degeneration (AMD), are directly associated with alterations of the Blood retinal barrier (BRB). In this review, the authors also mentioned tracer molecules for evaluating the blood retinal barrier integrity.
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血液视网膜屏障在药物吸收中的作用
血视网膜屏障是糖尿病患者视网膜最早的变化之一。血视网膜屏障是调节视网膜内外离子、蛋白质和水通量的生理屏障。在血视网膜屏障功能中,玻璃体荧光光度法是一种很好的定量方法。两种最相关的视网膜疾病是糖尿病视网膜病变和年龄相关性黄斑变性(AMD),它们与血液视网膜屏障(BRB)的改变直接相关。在这篇综述中,作者还提到了用于评估血液视网膜屏障完整性的示踪分子。
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