DANMEL: A manually curated reference database for analyzing mobile genetic elements associated with bacterial drug resistance.

IF 4.8 3区物理与天体物理 Q1 ASTRONOMY & ASTROPHYSICS Monthly Notices of the Royal Astronomical Society Pub Date : 2022-12-11 eCollection Date: 2022-12-01 DOI:10.1002/mlf2.12046

Peng Wang, Xiaoyuan Jiang, Kai Mu, Ying Jing, Zhe Yin, Yujun Cui, Cuidan Li, Xinhua Luo, Fangzhou Chen, Ting Yu, Zhichen Zhu, Yansong Sun, Fei Chen, Dongsheng Zhou

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Abstract

We have developed a manually curated online reference database, DANMEL (http://124.239.252.254/danmel/), that addresses the lack of accurate dissection and annotation of the genetic structures of mobile genetic elements (MGEs) with genes for drug resistance. DANMEL contains accurately annotated and genetically dissected reference MGEs covering 5 categories and 135 subcategories/subfamilies of MGEs. Further, DANMEL provides a detailed guide on how to precisely annotate MGEs. DANMEL also provides SEARCH/BLAST functions to facilitate finding reference MGEs. Overall, DANMEL will aid researchers to conduct in-depth genetic analysis of sequenced bacterial MGEs with drug-resistance genes and further facilitate a better understanding of bacterial MGEs associated with drug resistance at a genomic level.

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DANMEL：人工编辑的参考数据库，用于分析与细菌耐药性相关的移动遗传因子。

我们开发了一个人工编辑的在线参考数据库 DANMEL (http://124.239.252.254/danmel/)，以解决缺乏对带有耐药基因的移动遗传元件 (MGE) 的遗传结构进行精确剖析和注释的问题。DANMEL 包含经过准确注释和基因剖析的参考 MGEs，涵盖 5 个类别和 135 个亚类/亚家族的 MGEs。此外，DANMEL 还提供了如何精确注释 MGEs 的详细指南。DANMEL 还提供搜索/BLAST 功能，方便查找参考 MGE。总之，DANMEL 将帮助研究人员对带有耐药基因的测序细菌 MGEs 进行深入的遗传分析，并进一步促进在基因组水平上更好地了解与耐药性相关的细菌 MGEs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Monthly Notices of the Royal Astronomical Society ASTRONOMY & ASTROPHYSICS-

CiteScore

9.10

自引率

37.50%

发文量

3198

审稿时长

3 months

期刊介绍： Monthly Notices of the Royal Astronomical Society is one of the world''s leading primary research journals in astronomy and astrophysics, as well as one of the longest established. It publishes the results of original research in positional and dynamical astronomy, astrophysics, radio astronomy, cosmology, space research and the design of astronomical instruments.