Somatostatin Analog-Based Radiopharmaceuticals for Molecular Imaging and Therapy of Neuroendocrine Tumors

IF 0.7 Q4 PHARMACOLOGY & PHARMACY INDONESIAN JOURNAL OF PHARMACY Pub Date : 2022-05-11 DOI:10.22146/ijp.2514
Rien Ritawidya, C. Palangka, T. S. Humani, V. Y. Susilo, Ilma Darojatin, Anung Pujiyanto
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Abstract

Somatostatin receptors (SSTRs) are overexpressed in a wide variety of cancers such as neuroendocrine tumors (NETs), but the expression in normal cells is relatively low. Therefore, SSTRs serve a potential target for molecular imaging and therapeutic applications of NETs. This review presents the development of somatostatin analog-labeled with gamma-emitting radionuclides such as 111In, 99mTc, and 123I for the visualization of NETs via single-photon emission tomography (SPECT). Additionally, the development of somatostatin analog-radiolabeled with positron emitting radionuclide such as 68Ga for the molecular imaging of NETs with positron emission tomography (PET) is also presented herein. Moreover, this review describes 177Lu-, 90Y-, and 111In-labeled somatostatin analogs as peptide receptor radionuclide therapy (PRRT) agents for the therapeutic application of NETs. These radiolabeled-somatostatin analogs showed promising results with good images quality and high tumor uptake. These results highlight the potential application of radiopharmaceuticals-based somatostatin analogs for the molecular imaging and targeted treatment of NETs.
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基于生长抑素类似物的放射药物用于神经内分泌肿瘤的分子成像和治疗
生长抑素受体(SSTRs)在神经内分泌肿瘤(NETs)等多种癌症中过表达,但在正常细胞中的表达相对较低。因此,sstr是NETs分子成像和治疗应用的潜在靶点。本文综述了用γ -发射核素(如111In, 99mTc和123I)标记的生长抑素类似物的发展,用于通过单光子发射断层扫描(SPECT)显示NETs。此外,本文还介绍了用正电子发射核素(如68Ga)对生长抑素类似物进行放射性标记的研究进展,用于NETs的正电子发射断层扫描(PET)分子成像。此外,本文综述了177Lu-, 90Y-和111in标记的生长抑素类似物作为肽受体放射性核素治疗(PRRT)药物用于NETs的治疗应用。这些放射性标记的生长抑素类似物显示出良好的图像质量和高肿瘤摄取的前景。这些结果突出了基于放射性药物的生长抑素类似物在NETs分子成像和靶向治疗中的潜在应用。
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来源期刊
INDONESIAN JOURNAL OF PHARMACY
INDONESIAN JOURNAL OF PHARMACY PHARMACOLOGY & PHARMACY-
CiteScore
1.20
自引率
0.00%
发文量
38
审稿时长
12 weeks
期刊介绍: The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education. The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines.
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