Pharmacokinetics Study of Metformin – Mathematical Modelling and Simulation

Abstract

In the present investigation, a deterministic mathematical model of the pharmacokinetics of Metformin was developed using the first principle of chemical engineering (mass balance). The mathematical model developed with precision, can predict the concentration time history of the drug interest in stomach, liver, intestine, and the peripheral areas. According to this model, after administration, the drug is dissolved in the stomach following first order kinetics. The intestinal absorption of Metformin is majorly mediated by plasma membrane monoamine transporter. In liver Metformin takes part in various metabolic pathways which subsequently aid the adsorption of the drug in different cellular systems. No intermediate metabolites of Metformin have been identified till now. The major route for elimination of Metformin is through tubular secretion, in an unchanged form in the urine. The outcome of the predicted data closely matches the experimental finding, extracted after a meticulous scrutiny of the accessible literature, and results of clinical trials. The model is highly realistic and pragmatic in its practice.