A one pot, efficient and eco-friendly synthesis of 1,3,4-thiadiazolo[3,2-a] pyrimidine scaffold via Aza–Michael addition and intramolecular cyclo-elimination reactions in poly ethylene glycol (PEG)
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引用次数: 3
Abstract
Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of ethyl 2-substituted phenyl-7-oxo-7 H -[1,3,4]- thiadiazolo [3,2-a]- pyrimidine-6-corboxylate and -6-corbonitrile through intramolecular cyclo-elimination of Michael adducts formed between the reaction of 2-amino-5 substituted thiadiazoles with diethyl-2- (ethoxymethylene) malonate and ethyl-2- cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, 1 H and 13 C NMR, mass spectral data and elemental analyses.
聚乙烯醇-400中的碳酸钾是一种高效、直接、方便、通过分子内环消除2-氨基-5取代噻二唑与二乙基-2-(乙氧基亚甲基)丙二酸二乙酯和乙基-2-氰基-3-乙氧基丙烯酸酯反应形成的Michael加合物，一锅绿色合成了2-取代苯基-7-氧基-7 H -[1,3,4]-噻二唑[3,2-a]-嘧啶-6-羧酸酯和-6-腈。所有新化合物的结构已通过IR、1h和13c NMR、质谱数据和元素分析进行了鉴定。
期刊介绍：
Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".
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