Determination of Total Flavonoid Content and Initial Test of Anticancer Activity of Faloak Leaves and Fruit Extracts (Sterculia urceolata Smith)

Abstract

This study aimed to determine the total flavonoid content and anticancer activity of Faloak (Sterculiaurceolata Smith) leaves and fruit extracts. Brine Shrimp Lethality Test (BSLT) method determinedthe anticancer activity. Testing the total flavonoid content of n-hexane extract of the Faloak leavesand fruit were 1558.5 and 498.5 ppm, respectively. The total flavonoid content of the ethyl acetateextract of Faloak leaves and fruit were 876.5 and 621.8 ppm, respectively. The ethanol extract of Faloakleaves and fruit’s total flavonoid content was 338.5 and 1688.5 ppm. The anticancer activity test ofthe n-hexane extract of Faloak leaves and fruit showed that each extract’s LC50 value was 31.417and 50.736 ppm, respectively, and the LC50 value ethyl acetate extract of Faloak leaves and fruit were119.68 and 77.59 ppm. The LC50 value of ethanol extract of Faloak leaves and fruit were 43.82 and20.779 ppm, respectively. Both the leaves and fruit extract of Faloak had strong anticancer activity(<1000 ppm). However, the extracts with the strongest anticancer activity were the ethanol extract ofFaloak fruit and the n-hexane extract of Faloak leaves. Meanwhile, the extract with the highest amountof flavonoid content was the ethanol extract of Faloak fruit (1688.5 ppm), and the lowest amount wasethanol extract of the Faloak bark (4.5 ppm).