Sarah Stewart, Inidigo Lily Dean, Mark Lawlor, S. Lawrence
{"title":"The Use of Compaction Simulation as a Tool to Aid Successful Tablet Formulation","authors":"Sarah Stewart, Inidigo Lily Dean, Mark Lawlor, S. Lawrence","doi":"10.5920/bjpharm.1146","DOIUrl":null,"url":null,"abstract":"Early assessment of compaction properties of both APIs and formulations is an important consideration in early tablet development and can help to de-risk scale up from R&D to production scale. In this work, three model APIs and a tablet formulation were assessed using a compaction simulator. Compaction simulation was shown to be able to differentiate between the compaction properties of APIs and formulations and when combined with additional information on API properties (flowability, solubility) and tablet requirements (size, strength) can guide formulation strategy. ","PeriodicalId":9253,"journal":{"name":"British Journal of Pharmacy","volume":"3 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5920/bjpharm.1146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Early assessment of compaction properties of both APIs and formulations is an important consideration in early tablet development and can help to de-risk scale up from R&D to production scale. In this work, three model APIs and a tablet formulation were assessed using a compaction simulator. Compaction simulation was shown to be able to differentiate between the compaction properties of APIs and formulations and when combined with additional information on API properties (flowability, solubility) and tablet requirements (size, strength) can guide formulation strategy.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
