The efficacy of endovenously cyanoacrylate adhesive for the treatment of great saphenous vein insufficiency and mid-term follow-up results

Abstract

Objectives: This study aims to investigate the effectiveness and mid-term results of endovenous administration of n-butyl-2-cyanoacrylate (NBCA) in great saphenous vein (GSV) insufficiency. Patients and methods: A total of 77 lower extremity GSVs of 65 patients (23 males, 42 females; mean age: 53.7±16.8 years; range, 18 to 89 years) treated endovenously using NBCA between June 2018 and June 2019 were retrospectively analyzed. Clinical examination and color Doppler ultrasonographic examination were performed at 48 h and at 1, 3, 6, and 12 months after the procedure. The Comprehensive Classification System for Chronic Venous Disorders (CEAP) classification, Venous Clinical Severity Score (VCSS), and quality of life scores using the Aberdeen Varicose Vein Questionnaire (AVVQ ) were performed before and after the procedure. Results: Immediately after the procedure and at 48 h of follow-up, the GSV occlusion rate was 100%. The total occlusion rate was 97.4% at 12 months of follow-up. The mean VCSS improved from 5.9±1.5 at baseline to 0.8±0.6 at 12 months (p<001). The mean AVVQ scores improved from 15.4±3.6 at baseline to 3.8±0.7 at 12 months of follow-up (p<001). Conclusion: Endovenous treatment of GSV insufficiency with cyanoacrylate adhesive is a rapid and effective method and significantly improves the quality of life of patients. In addition, this procedure does not require the use of tumescent anesthesia and compression stockings.