{"title":"Quantitative morphology of the lung and its importance in investigations of pulmonary diseases in mice","authors":"Wilfried Klein","doi":"10.1016/j.ddmod.2019.09.002","DOIUrl":null,"url":null,"abstract":"<div><p>The morphology of the mouse respiratory system has been studied in several different models of respiratory diseases<span>, but quantitative morphological methods such as stereology are still only employed sporadically. This review discusses the use of stereology as a tool to understand the morphology of the mouse respiratory system and its link to the study of pulmonary mechanics. An integrated approach to study lung function in mice is being proposed, by combining non-invasive and invasive methods to analyze pulmonary mechanics, coupled with stereological investigations of lung morphology.</span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.09.002","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675719300210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
The morphology of the mouse respiratory system has been studied in several different models of respiratory diseases, but quantitative morphological methods such as stereology are still only employed sporadically. This review discusses the use of stereology as a tool to understand the morphology of the mouse respiratory system and its link to the study of pulmonary mechanics. An integrated approach to study lung function in mice is being proposed, by combining non-invasive and invasive methods to analyze pulmonary mechanics, coupled with stereological investigations of lung morphology.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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