Computational biology in topical bioactive peptide discovery for cosmeceutical application: a concise review

IF 0.6 Q4 ENGINEERING, BIOMEDICAL Biomedical Engineering: Applications, Basis and Communications Pub Date : 2023-01-01 DOI:10.53388/bmec2023014

Xu-Hui Li, Wenfeng Su, Feifei Wang, Ke Li, Jingjing Zhu, Si-Yu Zhu, Sishun Kang, Cong-Fen He, Jun-Xiang Li, Xiao-Ling Lin

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Abstract

Regenerative medicine and anti-aging research have made great strides at the molecular and cellular levels in dermatology and the medical aesthetic field, targeting potential treatments with skin therapeutic and intervention pathways, which make it possible to develop effective skin regeneration and repair ingredients. With the rapid development of computational biology, bioinformatics as well as artificial intelligence (A.I.), the development of new ingredients for regenerative medicine has been greatly accelerated, and the success rate has been improved. Some application cases have appeared in topical skin regeneration and repair scenarios. This review will briefly introduce the application of bioactive peptides in skin repair and anti-aging as emerging ingredients in cosmeceutics and emphasize how A.I. based computational biology technology may accelerate the development of innovative peptide molecules and ultimately translate them into potential skin regenerative and anti-aging scenarios. Typically, two research routines have been summarized and current limitations as well as directions were discussed for border applications in future research.

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计算生物学在药妆应用的局部生物活性肽发现:简要回顾

再生医学和抗衰老研究在皮肤病学和医学美学领域的分子和细胞水平上取得了巨大的进步，以皮肤治疗和干预途径为目标的潜在治疗方法，使开发有效的皮肤再生和修复成分成为可能。随着计算生物学、生物信息学和人工智能的快速发展，再生医学新成分的开发大大加快，成功率也有所提高。一些应用案例已经出现在局部皮肤再生和修复场景。本文将简要介绍生物活性肽作为新兴药妆成分在皮肤修复和抗衰老方面的应用，并强调基于人工智能的计算生物学技术如何加速创新肽分子的开发，并最终将其转化为潜在的皮肤再生和抗衰老场景。总结了两种典型的研究方法，并讨论了当前边界应用的局限性和未来研究的方向。

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来源期刊

Biomedical Engineering: Applications, Basis and Communications Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.50

自引率

11.10%

发文量

审稿时长

4 months

期刊介绍： Biomedical Engineering: Applications, Basis and Communications is an international, interdisciplinary journal aiming at publishing up-to-date contributions on original clinical and basic research in the biomedical engineering. Research of biomedical engineering has grown tremendously in the past few decades. Meanwhile, several outstanding journals in the field have emerged, with different emphases and objectives. We hope this journal will serve as a new forum for both scientists and clinicians to share their ideas and the results of their studies. Biomedical Engineering: Applications, Basis and Communications explores all facets of biomedical engineering, with emphasis on both the clinical and scientific aspects of the study. It covers the fields of bioelectronics, biomaterials, biomechanics, bioinformatics, nano-biological sciences and clinical engineering. The journal fulfils this aim by publishing regular research / clinical articles, short communications, technical notes and review papers. Papers from both basic research and clinical investigations will be considered.