Surgical Outcomes of Intracranial Meningiomas: A Retrospective Study

Abstract

Introduction: In this study, it was aimed to evaluate the clinical outcomes of patients who underwent surgical resection for meningioma. Methods: Medical records were retrospectively reviewed for all cranial and spinal cases diagnosed and underwent surgery at BRSHH Hospital between 2012 and 2016. All intracranial meningioma patients constituted the core sample for this study. Results: This series included 136 (88 females, 48 males) patients, with a mean age of 55.1±14.1 years. The mean preoperative course was 23.0±40.5 months. The most common symptom was headache (71.3%). The most common location was the frontal region which was seen in 29 patients (21.3%). The mean follow-up period was 36.0±18.95 months. 84.4% of grade I, and 68.2% of grade II demonstrated isointense lesions on T1-weighted magnetic resonance imaging (MRIs) (p=0.027). 15.5% of grade I and 47.7% of grade II showed irregularity (p=0.04). Giant tumors were more commonly associated with non-grade I meningiomas than grade I (p=0.006). 58.9% of grade I and 79.5% of grade II meningiomas demonstrated peritumoral edema on MRIs. The presence of preoperative neurological deficit (p<0.0001), irregularity on MRI (p=0.002), and recurrence (p=0.002) were associated with poor prognosis of surgical outcomes. Gross-total resection (GTR) (p=0.0003) was associated with a good prognosis. Discussion and Conclusion: The presence of preoperative neurological deficit, irregularity on MRI, and recurrence were factors associated with poor prognosis of surgical outcomes. GTR was associated with good surgical outcomes. The presence of preoperative deficits and irregularity on MRIs were associated with a high recurrence rate.