Neuroprotective Role of Statins in Alzheimer`s Disease: Anti-Apoptotic Signaling~!2009-02-06~!2010-04-04~!2010-06-22~!

Waylon T. Hunt, Pradeep Salins, C. Anderson, F. Amara
{"title":"Neuroprotective Role of Statins in Alzheimer`s Disease: Anti-Apoptotic Signaling~!2009-02-06~!2010-04-04~!2010-06-22~!","authors":"Waylon T. Hunt, Pradeep Salins, C. Anderson, F. Amara","doi":"10.2174/1874082001004010013","DOIUrl":null,"url":null,"abstract":"Alzheimer's disease (AD), a severe form of senile dementia is a neurodegenerative disorder. One of the most well characterized hallmarks of AD are extra-neuronal aggregates of amyloid-beta peptide (A� ), known as amyloid plaques. Recent epidemiological studies suggest a link between statin intake, and a lowered incidence of AD. Statins are 3-hydroxy-3-methylglutaryl co-enzyme reductase (HMG) inhibitors, which are one of the most commonly prescribed drug groups used to lower serum cholesterol levels in patients with heart disease. Some of the pleiotropic effects of statins which are gaining attention are its ability to reduce Aproduction and deposition, inhibit caspase-3 mediated apoptosis, and demonstrate anti-inflammatory properties by reducing interleukin-6 (IL-6) levels. The molecular mechanisms respon- sible for the pleiotropic effects of statins in promoting neuronal survival are not fully understood. Our own research has shown that statins promote anti-apoptotic responses against A� -neurotoxicity through � -catenin-TCF/LEF signaling how- ever, other anti-apoptotic statin mediated signaling pathways may also be involved. This review will describe AD patho- genesis, Aproduction, and the role of statins in mitigating these effects.","PeriodicalId":88753,"journal":{"name":"The open neuroscience journal","volume":"1 1","pages":"13-22"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The open neuroscience journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874082001004010013","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

Alzheimer's disease (AD), a severe form of senile dementia is a neurodegenerative disorder. One of the most well characterized hallmarks of AD are extra-neuronal aggregates of amyloid-beta peptide (A� ), known as amyloid plaques. Recent epidemiological studies suggest a link between statin intake, and a lowered incidence of AD. Statins are 3-hydroxy-3-methylglutaryl co-enzyme reductase (HMG) inhibitors, which are one of the most commonly prescribed drug groups used to lower serum cholesterol levels in patients with heart disease. Some of the pleiotropic effects of statins which are gaining attention are its ability to reduce Aproduction and deposition, inhibit caspase-3 mediated apoptosis, and demonstrate anti-inflammatory properties by reducing interleukin-6 (IL-6) levels. The molecular mechanisms respon- sible for the pleiotropic effects of statins in promoting neuronal survival are not fully understood. Our own research has shown that statins promote anti-apoptotic responses against A� -neurotoxicity through � -catenin-TCF/LEF signaling how- ever, other anti-apoptotic statin mediated signaling pathways may also be involved. This review will describe AD patho- genesis, Aproduction, and the role of statins in mitigating these effects.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
他汀类药物在阿尔茨海默病中的神经保护作用:抗凋亡信号传导
阿尔茨海默病(AD)是一种严重的老年痴呆症,是一种神经退行性疾病。阿尔茨海默病最明显的特征之一是淀粉样蛋白-肽(α)的神经元外聚集,称为淀粉样斑块。最近的流行病学研究表明,他汀类药物的摄入与降低阿尔茨海默病发病率之间存在联系。他汀类药物是3-羟基-3-甲基戊二酰辅酶还原酶(HMG)抑制剂,是用于降低心脏病患者血清胆固醇水平的最常用处方药之一。他汀类药物的一些多效性作用正在引起人们的关注,包括它能够减少a的产生和沉积,抑制caspase-3介导的细胞凋亡,并通过降低白细胞介素-6 (IL-6)水平表现出抗炎特性。他汀类药物促进神经元存活的多效作用的分子机制尚不完全清楚。我们自己的研究表明,他汀类药物通过-catenin- tcf /LEF信号通路促进A -神经毒性的抗凋亡反应,然而,他汀类药物介导的其他抗凋亡信号通路也可能参与。这篇综述将描述AD的发病机制,a的产生,以及他汀类药物在减轻这些影响中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Modulation of Extracellular Levels of 5-HT in the Caudate Putamen of Freely Moving Rats by High Frequency Stimulation of the Subthalamic Nucleus Azathioprine Therapy in Multiple Sclerosis: Phosphoribosylated Metabolites and Thiopurine Methyltransferase Activity Menthol Induces Surgical Anesthesia and Rapid Movement in Fishes BDNF promotes the survival of rat sensory epithelial cells via the PI3K/Akt and NF-κB/Bcl-2 signaling pathways Neural Dynamics of Audiovisual Integration for Speech and Non-Speech Stimuli: A Psychophysical Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1