The clinicopathological and prognostic significance of PD-1 expression in cancers: A bioinformatics analysis

Shuai Shi, Zhi-Gang Zhang, Guangtao Ma, Hongyan Ma
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引用次数: 1

Abstract

Background: Programmed cell death protein 1 (PD-1), which is encoded by PDCD1 gene, is a cell-surface protein of immunoglobin family. A number of published studies have reported the relationship between PD-1 expression and prognosis in cancers. The purpose of our study was to identify an independent prognostic marker. Methods: In the present study, we investigated the prognostic value of PD-1 mRNA expression through the Kaplan–Meier plotter databases. Results: The expression of PD-1 mRNA was negatively related with the overall survival (OS) rate of gastric cancer, but positively associated with the OS rate of breast cancer, ovarian cancer and liver cancer (P < 0.05). High PD-1 mRNA expression was linked to an improved relapse-free survival rate of breast cancer, ovarian cancer, and liver cancer (P < 0.05). There was a negative correlation with post-progression survival in gastric cancer (P < 0.05). Besides, there was a positive correlation with progression-free survival and disease specific survival in liver cancer. We also further evaluated the prognostic value of PD-1 in relation to different clinicopathological features of cancers. Conclusion: Our results showed that PD-1 expression might be a good marker for the prognosis of patients with cancers, which highlights new methods and ideas for preventive treatment.
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肿瘤中PD-1表达的临床病理和预后意义:生物信息学分析
背景:程序性细胞死亡蛋白1 (Programmed cell death protein 1, PD-1)是免疫球蛋白家族的一种细胞表面蛋白,由PDCD1基因编码。许多已发表的研究报道了PD-1表达与癌症预后之间的关系。我们研究的目的是确定一个独立的预后指标。方法:在本研究中,我们通过Kaplan-Meier绘图仪数据库研究PD-1 mRNA表达的预后价值。结果:PD-1 mRNA表达与胃癌总生存率呈负相关,与乳腺癌、卵巢癌、肝癌总生存率呈正相关(P < 0.05)。PD-1 mRNA的高表达与乳腺癌、卵巢癌和肝癌的无复发生存率的提高有关(P < 0.05)。与胃癌进展后生存率呈负相关(P < 0.05)。此外,与肝癌的无进展生存期和疾病特异性生存期呈正相关。我们还进一步评估了PD-1与不同癌症临床病理特征的预后价值。结论:PD-1的表达可能是癌症患者预后的良好标志,为预防治疗提供了新的方法和思路。
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