The effect of metal particles from a nickel refinery dump on alveolar macrophages. Part 1—Chamber exposure of Wistar rats

Environmental Pollution Series A, Ecological and Biological Pub Date : 1986-01-01 DOI:10.1016/0143-1471(86)90059-0

E. Reichrtová, Z. Kováčiková, Ľ. Takáč, C. Oravec

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引用次数: 3

Abstract

The effect of long-term respiratory chamber exposure to aerosol containing metal particles derived from a nickel refinery dump on the alveolar macrophage (AM) phagocytic and enzymatic activities of Wistar rats was investigated. The number of AM lavaged from the lungs of the exposed group was significantly higher than in the controls (P < 0·001). The lung lavage exhibited some pleomorphic cells. The high number (93%) of AM with phagocytised metal particles was detected. In vitro the lavaged cells showed a significant increase in ⁵¹Cr incorporation compared to the control group. A statistically significant enhancement of AM lysosomal (acid phosphatase and β-glucuronidase) enzyme activities (P < 0·05, P < 0·01) was found in the exposed animals, whereas both the plasma membrane (ATPase and 5′-nucleotidase) enzyme activities were clearly reduced (P < 0·001). Serum cytotoxicity in the exposed animals was slightly elevated.

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镍冶炼厂废弃金属颗粒对肺泡巨噬细胞的影响。第一部分:Wistar大鼠的室内暴露

研究了长期暴露于含镍冶炼厂废弃物金属颗粒气溶胶对Wistar大鼠肺泡巨噬细胞(AM)吞噬和酶活性的影响。暴露组肺灌洗AM的数量明显高于对照组(P <0·001)。肺灌洗液显示一些多形性细胞。检测到大量(93%)金属颗粒被吞噬的AM。体外灌洗后的细胞与对照组相比，51Cr掺入量显著增加。AM溶酶体(酸性磷酸酶和β-葡萄糖醛酸酶)酶活性显著增强(P <0·05,P <0·01)，而质膜(atp酶和5′-核苷酸酶)活性明显降低(P <0·001)。暴露动物的血清细胞毒性略有升高。

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