{"title":"Zinc Links in a Receptor-Kinase Complex","authors":"","doi":"10.1126/scisignal.2012003tw369","DOIUrl":null,"url":null,"abstract":"Association of the T cell coreceptors CD-4 and CD-8 with the cytoplasmic kinase Lck regulates T cell activation and maturation. Kim et al. have explored the requirement for zinc in this interaction and report that the metal ion acts as a clasp that stabilizes a receptor-Lck complex. Peptides corresponding to a short region of Lck and in either receptor's cytoplasmic tail were unordered, but the presence of zinc induced the synergistic mutual folding of the peptides. Protein modifications could unlatch the clasp and modulate receptor-Lck binding. P. W. Kim, Z.-Y. J. Sun, S. C. Blacklow, G. Wagner, M. J. Eck, A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science 301, 1725-1728 (2003). [Abstract] [Full Text]","PeriodicalId":21619,"journal":{"name":"Science's STKE","volume":"5 1","pages":"TW369 - tw369"},"PeriodicalIF":0.0000,"publicationDate":"2003-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science's STKE","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1126/scisignal.2012003tw369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Association of the T cell coreceptors CD-4 and CD-8 with the cytoplasmic kinase Lck regulates T cell activation and maturation. Kim et al. have explored the requirement for zinc in this interaction and report that the metal ion acts as a clasp that stabilizes a receptor-Lck complex. Peptides corresponding to a short region of Lck and in either receptor's cytoplasmic tail were unordered, but the presence of zinc induced the synergistic mutual folding of the peptides. Protein modifications could unlatch the clasp and modulate receptor-Lck binding. P. W. Kim, Z.-Y. J. Sun, S. C. Blacklow, G. Wagner, M. J. Eck, A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science 301, 1725-1728 (2003). [Abstract] [Full Text]
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
